Development of the first way to make large amounts of promising anti-cancer substance


AMF-26

Development of the first way to make large amounts of promising anti-cancer substance

Author
- American Chemical Society By Isamu Shiina, Ph.D.  Wednesday, January 16, 2013
| Print friendly | Email Us

Scientists are reporting development of the first practical way to make large amounts of a promising new anti-cancer substance that kills cancer cells differently than existing medicines. Their article on synthesis of the substance, and tests demonstrating its effectiveness in the laboratory, appears in ACS’ Journal of Medicinal Chemistry.

Isamu Shiina and colleagues explain that the substance, AMF-26, showed promise against certain forms of cancer in laboratory studies, fostering excitement about its potential for development as a new anti-cancer drug. That excitement centered on AMF-26’s action in targeting a structure in cells, the Golgi apparatus, that had never been exploited in the past. The Golgi apparatus sorts and modifies hormones, enzymes and other key proteins for transport elsewhere. However, AMF-26 had been available in only small amounts by semisynthesis starting from AMF-14, which was extracted from the common soil mold of the genus Trichoderma.

Their report describes the first successful practical synthesis of AMF-26 and laboratory tests showing that the synthetic AMF-26 is just as effective as its natural counterpart. “The large-scale production of AMF-26 and its derivatives for the development of novel anticancer drugs are now in progress in this laboratory,” the report states.

The authors acknowledge funding from Health and Labour Sciences Research Grants from the Ministry of Health, Labour and Welfare, Japan.

Total Synthesis of AMF-26, an Antitumor Agent for Inhibition of the Golgi System, Targeting ADP-Ribosylation Factor 1

Disqus Comments

American Chemical Society, ACS is a congressionally chartered independent membership organization which represents professionals at all degree levels and in all fields of chemistry and sciences that involve chemistry.

Learn more about ACS.






Most Shared CFP stories



What's New On CFP:

  1. Climate issues we do need to address
    By Paul Driessen -- --Global Warming-Energy-Environment
  2. Clinton secrets hacked by spy in bag
    By News on the Net --
  3. SOS to Pope Francis: It’s souls that need saving, not the environment
    By Judi McLeod -- --Cover Story
  4. Jeb! asks George! for Help
    By Arthur Christopher Schaper -- --Cover Story
  5. Trump vs. Ramos Bout
    By Obie Usategui -- --Cover Story
  6. UN Gun Control Body Supported By Obama Sets Up Veto-Proof Framework
    By News on the Net -- --News Headlines
  7. Thousands of people trying to enter countries both legally and illegally, spreading diseases
    By Guest Column -- --Letter
  8. The Cadillac Tax is a heap of junk
    By Herman Cain -- --American Healthcare
  9. Liberalism Created the WDBJ Killer
    By Selwyn Duke -- --American Politics
  10. Why the Supreme Court is not Supreme
    By Matt Barber -- --American Politics
  11. Latest World News
    By News on the Net -- --News Features
  12. Lion kills safari guide in Zimbabwe park where Cecil lived
    By News on the Net -- --News Headlines
  13. Israel and the United States: Time for a Parallel Agreement
    By INSS -- --World News
  14. A Proposal for the Muslim Refugees Clamoring to Enter Europe
    By Dr. Norman Berdichevsky -- --Cover Story
  15. Hate and Anger are not mental Illnesses
    By Mike Foil -- --Cover Story
  16. Donald Trump’s stance on illegal immigration
    By Al Kaltman -- --American Politics
  17. Dead wrong: Mugabe promises Zim will get China-driven economic growth
    By News on the Net -- --News Headlines
  18. Biased Media vs. Behavioral Standards
    By Lloyd Marcus -- --American Politics
  19. Admiral James Lyons on Iran Nuke Deal [Video]
    By News on the Net -- --American Politics
  20. Sarah Palin-Donald Trump Interview
    By News on the Net -- --American Politics
  21. Texas deputy killed ‘execution-style’ while fueling patrol car, authorities say
    By News on the Net -- --News Headlines
  22. Constitutionality of Planned Parenthood Defunding Plans
    By Douglas V. Gibbs -- --Cover Story
  23. Boehner is typical of Jackass GOP Leaders
    By Jeff Crouere -- --Cover Story
  24. Full, Unedited 8th Video Confirms Planned Parenthood Sells Fully Intact Aborted Babies(video)
    By News on the Net -- --News Headlines
  25. Camp Lone Star – Massey is Protected by State Law
    By Gary Hunt -- --American Freedom
  26. The Vinoy Renaissance Celebrates 90th Anniversary With “90 Years An Icon”
    By News on the Net -- --Vacation Resorts, Travel
  27. How This New Government Ruling Destroys the Franchise Business Model
    By Heritage Foundation -- --News Headlines
  28. Kentucky Clerk Appeals to the Supreme Court
    By Liberty Counsel -- --American Freedom
  29. Judicial Watch Files Amicus Brief Asking Supreme Court
    By News on the Net -- --American Politics
  30. The Ayatollahs consider the US their chief target
    By Yoram Ettinger -- --American Politics










Caruba: Professional Writing Services