Toward a pill to enable celiac patients to eat foods containing gluten


KumaMax

Toward a pill to enable celiac patients to eat foods containing gluten

Author
- American Chemical Society By Justin B. Siegel, Ph.D.  Wednesday, January 30, 2013
| Print friendly | Email Us

Scientists are reporting an advance toward development of a pill that could become celiac disease’s counterpart to the lactase pills that people with lactose intolerance can take to eat dairy products without risking digestive upsets. They describe the approach, which involves an enzyme that breaks down the gluten that causes celiac symptoms, in the Journal of the American Chemical Society.

Justin Siegel, Ingrid Swanson Pultz and colleagues explain that celiac disease is an autoimmune disorder in which the gluten in wheat, rye or barley products causes inflammation in the digestive tract. Enzymes in the stomach break down gluten into smaller pieces, called peptides. For most people, these peptides are harmless. But for the 2 million-3 million Americans with celiac disease, the peptides trigger an autoimmune response and painful symptoms. Currently, the only treatment is a gluten-free diet. However, the scientists reasoned that if an enzyme could further break down the offending peptides in the stomach, celiac patients might be able to eat gluten-containing foods.

They describe discovery of a naturally occurring enzyme that has some of the ideal properties for doing so. The scientists modified the enzyme in the laboratory so that it would meet all the necessary criteria. The new enzyme (called KumaMax) broke down more than 95 percent of a gluten peptide implicated in celiac disease in acidic conditions like those in the stomach. “These combined properties make the engineered [enzyme] a promising candidate as an oral therapeutic for celiac disease,” say the researchers.

Full article

Disqus Comments

American Chemical Society, ACS is a congressionally chartered independent membership organization which represents professionals at all degree levels and in all fields of chemistry and sciences that involve chemistry.

Learn more about ACS.






Most Shared CFP stories



What's New On CFP:

  1. The Ayatollahs consider the US their chief target
    By Yoram Ettinger -- --American Politics
  2. The Myth of Climate Tipping Points
    By Dr. Klaus L.E. Kaiser -- --Global Warming-Energy-Environment
  3. Minnesota Terror suspect granted class-A truck driving license.  Would like to drive school buses
    By Robert Laurie -- --Crime-Terror-Security
  4. Hillary: Republicans who want to defund Planned Parenthood are pretty much terrorists
    By Robert Laurie -- --American Politics
  5. My cancellation
    By Guest Column -- --Letter
  6. Libya recovers 82 bodies after migrant boat sinks, more feared dead
    By News on the Net -- --News Headlines
  7. The Children of Illegal Immigrants Are Not Born American Citizens
    By Tim Dunkin -- --Cover Story
  8. Our Immigration System Is Not Broken
    By Dr. Robert R. Owens -- --Cover Story
  9. Kurds Are Surging – America Is Not
    By Eddie Pedersen -- --Cover Story
  10. Major Disaster Requires God, Groceries, Gold, Guns, Garden!
    By Dr. Don Boys -- --American Politics
  11. Preschoolers Solve LA’s Homeless Veteran Problem
    By Robert L. Rosebrock -- --American Politics
  12. At Last: Britain Signals End Of Solar Subsidies
    By Guest Column -- --Global Warming-Energy-Environment
  13. Your wonderful analysis of American Illegal alien situation
    By Guest Column -- --Letter
  14. Black Pastors Demand Smithsonian Remove Planned Parenthood Founder’s Bust
    By Heritage Foundation -- --News Headlines
  15. Oh, How the Mighty Megyn Has Fallen
    By Joan Swirsky -- --Media - Media Bias
  16. Hillary Takes “Responsibility” for Email Abuses
    By Matthew Vadum -- --American Politics
  17. Paying the Media for Pro-U.N. Coverage
    By Cliff Kincaid -- --Cover Story
  18. Thomas More Society Defends David Daleiden: He Uncovers Abortion Industry’s Sale of Fetal Body Parts
    By Christian Newswire -- --American Politics
  19. Obama: Regulators will never approve those massive health premium increases; Regulators: APPROVED
    By Dan Calabrese -- --American Healthcare
  20. Hillary Clinton Compares Pro-Lifers to Terrorists
    By News on the Net -- --News Headlines
  21. PAKISTAN: Young Christian Women Trapped into Forced Conversions
    By News on the Net -- --Christianity - Religion
  22. The pistol-packing Mr Big growing fat on migrants who will do ANYTHING to reach Britain
    By News on the Net -- --News Headlines
  23. Migrant ghost ships: Who are the people smugglers?
    By News on the Net -- --News Headlines
  24. Hunger by Government Definition Is “Food Insecure”
    By Dr. Ileana Johnson Paugh -- --Cover Story
  25. Ebeneezer Biden: Better at Giving Away Your Money Than His
    By William Kevin Stoos -- --Cover Story
  26. Planned Parenthood Audit Rejected
    By Douglas V. Gibbs -- --Cover Story
  27. Feminists, Lunacy, And The Southern Belle
    By Gail Jarvis -- --American Politics
  28. Quebec Law Would Stifle Criticism of Radical Islam
    By News on the Net -- --News Headlines
  29. Center for Medical Progress Calls Planned Parenthood-Commissioned Analysis of Videos ‘Complete
    By Heritage Foundation -- --News Headlines
  30. Mitsubishi upgrades its RVR for 2015
    By Jim Bray -- --Automotive News and Reviews










Caruba: Professional Writing Services