AMF-26

Development of the first way to make large amounts of promising anti-cancer substance

Author
- American Chemical Society By Isamu Shiina, Ph.D.  Wednesday, January 16, 2013
| Print friendly | Email Us

Scientists are reporting development of the first practical way to make large amounts of a promising new anti-cancer substance that kills cancer cells differently than existing medicines. Their article on synthesis of the substance, and tests demonstrating its effectiveness in the laboratory, appears in ACS’ Journal of Medicinal Chemistry.

Isamu Shiina and colleagues explain that the substance, AMF-26, showed promise against certain forms of cancer in laboratory studies, fostering excitement about its potential for development as a new anti-cancer drug. That excitement centered on AMF-26’s action in targeting a structure in cells, the Golgi apparatus, that had never been exploited in the past. The Golgi apparatus sorts and modifies hormones, enzymes and other key proteins for transport elsewhere. However, AMF-26 had been available in only small amounts by semisynthesis starting from AMF-14, which was extracted from the common soil mold of the genus Trichoderma.

Their report describes the first successful practical synthesis of AMF-26 and laboratory tests showing that the synthetic AMF-26 is just as effective as its natural counterpart. “The large-scale production of AMF-26 and its derivatives for the development of novel anticancer drugs are now in progress in this laboratory,” the report states.

The authors acknowledge funding from Health and Labour Sciences Research Grants from the Ministry of Health, Labour and Welfare, Japan.

Total Synthesis of AMF-26, an Antitumor Agent for Inhibition of the Golgi System, Targeting ADP-Ribosylation Factor 1

Disqus Comments

American Chemical Society, ACS is a congressionally chartered independent membership organization which represents professionals at all degree levels and in all fields of chemistry and sciences that involve chemistry.

Learn more about ACS.






Most Shared CFP stories



What's New On CFP:

  1. Latest American News
    By News on the Net -- --News Headlines
  2. Latest News from Ferguson, Missouri
    By News on the Net -- --News Headlines
  3. Clinton to keynote jellyfish journalist gathering, but no questions allowed
    By Judi McLeod -- --Cover Story
  4. ISIS: Outcome of a failed policy toward Iran
    By Guest Column -- --Cover Story
  5. Dante’s Hell
    By Church Militant -- --Christianity - Religion
  6. ‘A Strategy Doomed to Failure’: Conservatives Fault GOP Leadership After Homeland Securi
    By Heritage Foundation -- --American Politics
  7. Latest News On ISIS and Radical Islam
    By News on the Net -- --News Headlines
  8. Latest World News
    By News on the Net -- --News Headlines
  9. Top U.K. University Blacklists Israeli Academic Institutions
    By Arnold Ahlert -- --Cover Story
  10. Media Cheerleading for Obamacare Victory at Supreme Court
    By Roger Aronoff -- --Media - Media Bias
  11. Life under the US umbrella
    By Caroline Glick -- --World News
  12. Media Bias: CNN Lies Saying GOP Wants to ‘End Health Care for Millions
    By Warner Todd Huston -- --Media - Media Bias
  13. Well, that’s weird.The Hillary Clinton of ‘07 thought secret email accounts ‘shredded the Constituti
    By Robert Laurie -- --American Politics
  14. SYRIA: Concern Continues for Abducted Christians
    By News on the Net -- --Christianity - Religion
  15. EPA to Regulate Methane Emissions Despite Huge Decline
    By Institute for Energy Research -- --Global Warming-Energy-Environment
  16. Latest News on Business and the Economy
    By News on the Net -- --News Headlines
  17. The Rise of Prosecutorial Abuses
    By Alan Joel -- --American Politics
  18. Obama, Hillary, Muslim Brotherhood and a secret email server
    By Dag Barkley -- --Cartoons
  19. Prime Minister Netanyahu’s Purpose in Addressing the US Congress on Iran
    By Rabbi Dr. Daniel M. Zucker -- --Cover Story
  20. Chicago on the Potomac
    By Dr. Robert R. Owens -- --Cover Story
  21. Netanyahu’s Incredibly Heart-Felt Plea: How Could Dems look in their mirrors the next morning?
    By Jerry McConnell -- --Cover Story
  22. Welcome to the New Journalism Where Media Mob Mentality rules.
    By Diane Weber Bederman -- --Cover Story
  23. Blaming the Baby Boomers for the Economy
    By Guest Column -- --Letter
  24. Wynne and Sandals have lied to the Public
    By News on the Net -- --Canada
  25. Latest News on Ebola and Infectious Diseases
    By News on the Net -- --News Headlines
  26. Turning our country over to the Muslims
    By Guest Column -- --Letter
  27. MSNBC: Hillary’s email claims are ‘insulting’ our intelligence. ‘Absolute nonsense’
    By Robert Laurie -- --Media - Media Bias
  28. Hillary: Hey, I’ve told the State Department to release my e-mails
    By Dan Calabrese -- --American Politics
  29. US Shale Oil Keeps Booming Despite Low Prices - For Now
    By Guest Column -- --Global Warming-Energy-Environment
  30. Hillary Will Not Run for President
    By Alan Caruba -- --Cover Story









Caruba: Professional Writing Services



Pursuant to Title 17 U.S.C. 107, other copyrighted work is provided for educational purposes, research, critical comment, or debate without profit or payment. If you wish to use copyrighted material from this site for your own purposes beyond the 'fair use' exception, you must obtain permission from the copyright owner.

Views are those of authors and not necessarily those of Canada Free Press. Content is Copyright 1997-2014 the individual authors.

Site Copyright 1997-2014 Canada Free Press.Com Privacy Statement


Powered by ExpressionEngine