hit tracker


AMF-26

Development of the first way to make large amounts of promising anti-cancer substance

Author
- American Chemical Society By Isamu Shiina, Ph.D.  Wednesday, January 16, 2013
| Print friendly | Email Us

Scientists are reporting development of the first practical way to make large amounts of a promising new anti-cancer substance that kills cancer cells differently than existing medicines. Their article on synthesis of the substance, and tests demonstrating its effectiveness in the laboratory, appears in ACSā€™ Journal of Medicinal Chemistry.

Isamu Shiina and colleagues explain that the substance, AMF-26, showed promise against certain forms of cancer in laboratory studies, fostering excitement about its potential for development as a new anti-cancer drug. That excitement centered on AMF-26ā€™s action in targeting a structure in cells, the Golgi apparatus, that had never been exploited in the past. The Golgi apparatus sorts and modifies hormones, enzymes and other key proteins for transport elsewhere. However, AMF-26 had been available in only small amounts by semisynthesis starting from AMF-14, which was extracted from the common soil mold of the genus Trichoderma.

Their report describes the first successful practical synthesis of AMF-26 and laboratory tests showing that the synthetic AMF-26 is just as effective as its natural counterpart. “The large-scale production of AMF-26 and its derivatives for the development of novel anticancer drugs are now in progress in this laboratory,” the report states.

The authors acknowledge funding from Health and Labour Sciences Research Grants from the Ministry of Health, Labour and Welfare, Japan.

ā€œTotal Synthesis of AMF-26, an Antitumor Agent for Inhibition of the Golgi System, Targeting ADP-Ribosylation Factor 1ā€

Scroll down this page for Disqus Comments |

American Chemical Society, ACS is a congressionally chartered independent membership organization which represents professionals at all degree levels and in all fields of chemistry and sciences that involve chemistry.

Learn more about ACS.






Most Shared CFP stories



What's New On CFP:

  1. Latest American News
    By News on the Net -- --News Headlines
  2. Michelle Obama causes backlash by foregoing a headscarf while in Saudi Arabia - well done
    By Robert Laurie -- --American Politics
  3. Government TV mocks bid to repeal government health care
    By Dan Calabrese -- --American Politics
  4. Refreshing Honesty from James Hansen on Climate Policies
    By Institute for Energy Research -- --Global Warming-Energy-Environment
  5. Nova Scotia Supreme Court Sends Strong Message To Law Societies Refusing To Recognize Christian Law
    By News on the Net -- --Canada
  6. Latest News On ISIS and Radical Islam
    By News on the Net -- --News Headlines
  7. Sgt. Bowe Bergdahl
    By Dag Barkley -- --Cartoons
  8. Indiana’s Mike Pence Latest Republican Governor to Expand Medicaid
    By Heritage Foundation -- --American Healthcare
  9. Latest World News
    By News on the Net -- --News Headlines
  10. Here we go: Scott Walker’s committee releases first campaign ad - takes a shot at retread candidates
    By Robert Laurie -- --American Politics
  11. Beer compound could help fend off Alzheimer’s and Parkinson’s diseases
    By American Chemical Society -- --Medical News
  12. Casa de Campo Invites Vacationers to Book Early and Save with Limited-Time “Always Summer in C
    By News on the Net -- --Vacation Resorts, Travel
  13. Detecting chemical weapons with a color-changing film
    By American Chemical Society -- --Science-Technology
  14. U.S. Settles Suit Over Misuse of West L.A. Veterans Campus
    By Robert L. Rosebrock -- --American Life, History, Education
  15. The Doomsday Clock
    By Dr. Klaus L.E. Kaiser -- --Global Warming-Energy-Environment
  16. World’s smallest, cheapest patch pump for diabetics
    By Guest Column -- --Medical News
  17. More wind power will increase hydro rates
    By Guest Column -- --Global Warming-Energy-Environment
  18. Islam and Terrorism: A Futile Debate
    By INSS -- --World News
  19. Terrorists
    By William Bedford -- --Letter
  20. Your 529 Plan Is Safe. Here’s Why the White House Changed Course
    By Heritage Foundation -- --American Politics
  21. Eyeglasses that turn into sunglasses — at your command
    By American Chemical Society -- --Science-Technology
  22. The Michelle Obama Valerie Jarrett Publicity Hound Tag Team
    By Judi McLeod -- --Cover Story
  23. An Auschwitz Anniversary
    By Alan Caruba -- --Cover Story
  24. Refineries challenge EPA plan to cut emissions
    By American Chemical Society -- --Global Warming-Energy-Environment
  25. Wynne Is Promising More Debt, Not Less
    By Canadian Taxpayers Federation -- --Canada
  26. Lies And Deception In Ukraine’s Energy Sector
    By Oilprice.com -- --Global Warming-Energy-Environment
  27. Obama’s Economic Shell Game
    By Guest Column -- --American Politics
  28. The Northeast Nanny-staters Who are and the Blizzard that Never Was
    By Selwyn Duke -- --American Politics
  29. Film narrator: Obama’s missed calling
    By A. Dru Kristenev -- --Cover Story
  30. Obama’s Proposed Capital Gains Rate Hikes Will Hurt the Economy
    By Alan Joel -- --Cover Story







Caruba: Professional Writing Services



Pursuant to Title 17 U.S.C. 107, other copyrighted work is provided for educational purposes, research, critical comment, or debate without profit or payment. If you wish to use copyrighted material from this site for your own purposes beyond the 'fair use' exception, you must obtain permission from the copyright owner.

Views are those of authors and not necessarily those of Canada Free Press. Content is Copyright 1997-2014 the individual authors.

Site Copyright 1997-2014 Canada Free Press.Com Privacy Statement


Powered by ExpressionEngine

{/exp:ce_cache:it}