Subtherapeutic doses

Microdosing: Updating its role in developing new medicines

Author
- American Chemical Society  Wednesday, January 23, 2013
| Print friendly | Email Us

One of yesterday’s most promising new tools for speeding the development of new medicines — “microdosing” — has found niches in that process today, and they include uses unanticipated a decade ago. That topic, an update on microdosing, is the cover story in the current edition of Chemical & Engineering News. C&EN is the weekly newsmagazine of the American Chemical Society, the world’s largest scientific society.

C&EN Senior Editor Celia Henry Arnaud explains that microdosing offered promise for helping pharmaceutical companies identify potential failures earlier, before starting full-fledged clinical trials of a potential new drug. It involves giving subtherapeutic doses — 1 percent of the full dose — to human volunteers after minimal animal testing. Scientists then would use the results to determine whether to move ahead with expensive safety testing in traditional Phase 1 clinical trials. Microdosing promised to become a standard part of drug development, adding a new so-called Phase 0 to that process.

The article points out that occasional Phase 0 clinical trials do, indeed, take place. But microdosing most often is used in “absolute bioavailability studies,” done in parallel with standard clinical trials to determine how much of the drug actually reaches its target tissue to treat the disease. Other uses of microdosing may emerge in the years ahead, the article notes.

More…

Disqus Comments

American Chemical Society, ACS is a congressionally chartered independent membership organization which represents professionals at all degree levels and in all fields of chemistry and sciences that involve chemistry.

Learn more about ACS.






Most Shared CFP stories



What's New On CFP:

  1. Latest American News
    By News on the Net -- --News Headlines
  2. The Uncertainty Over Adam and Eve’s Skin Colors
    By Sierra Rayne -- --Christianity - Religion
  3. VIDEO: Is Hillary Trustworthy? Hardly!
    By Warner Todd Huston -- --American Politics
  4. Camp Lone Star—The Setup—Get Massey
    By Gary Hunt -- --American Freedom
  5. A Godly Right to Privacy
    By Douglas V. Gibbs -- --Cover Story
  6. At Pro-Life Event, Rand Paul Jabs Hillary Clinton on Women’s Rights
    By Heritage Foundation -- --American Politics
  7. Who is the Real Hillary Clinton?
    By Chuck Lehmann -- --American Politics --Letter
  8. CCRKBA Chairman Notes Gun Owners Are Voters, Too
    By CCRKBA -- --Gun Control - Second Amendment
  9. Let’s All Celebrate ‘Earth is for People Day’
    By Christian Newswire -- --American Politics
  10. Clinton Campaign Credibility Questioned
    By News on the Net -- --Video
  11. Time for American Taxpayers to revolt
    By Jeff Crouere -- --Cover Story
  12. Another Victory Over ObamaCare Abortion Mandate
    By Liberty Counsel -- --American Freedom
  13. Attempts to stifle debate by far-left House members are reminiscent of McCarthy era
    By Guest Column -- --American Politics
  14. Make Crown Expenses Transparent
    By Canadian Taxpayers Federation -- --Canada
  15. Lien Forward: Pro-tax MSNBC host, Melissa Harris-Perry, facing $70,000.00 IRS lien
    By Robert Laurie -- --Media - Media Bias
  16. India To Overtake China As The World’s Biggest Coal Importer
    By Guest Column -- --Global Warming-Energy-Environment
  17. Hillary…Normal people don’t steer from the back seat!
    By Dag Barkley -- --Cartoons
  18. CBC’s Ghomeshi Report Rejected as Whitewash
    By Mitch Wolfe -- --Media - Media Bias
  19. American Jewry’s Moment of Decision
    By Caroline Glick -- --American Politics
  20. More Judicial Activism
    By Guest Column -- --Letter
  21. House GOP Plans Secret Vote to Determine Export-Import Bank’s Future
    By Heritage Foundation -- --American Politics
  22. Now it’s the Bible that’s sexist
    By Judi McLeod -- --Cover Story
  23. Rand Paul (video): So why does Hillary take so much money from abusers of women’s rights?
    By Dan Calabrese -- --Cover Story
  24. Clinton Campaign Chaos
    By Matthew Vadum -- --Cover Story
  25. Remember: Sic Semper Tyrannis
    By Tabitha Korol -- --American Politics
  26. Sunday’s Special Celebration - Don’t miss it!
    By Robert L. Rosebrock -- --American Politics
  27. Chelsea lending a hand with Hillary’s campaign!
    By Dag Barkley -- --Cartoons
  28. Judith Miller Opens Old Iraq War Wounds, and Sheds Some New Light
    By Roger Aronoff -- --Media - Media Bias
  29. EIA’s Annual Energy Outlook 2015: Fossil Fuels Remain Predominant Energy Providers
    By Institute for Energy Research -- --Global Warming-Energy-Environment
  30. COTE D’IVOIRE: Christian Woman Abandoned by Husband
    By News on the Net -- --Christianity - Religion


Ford Nation

Why hundreds of thousands of Torontonians supported their conservative crack-smoking mayor













Caruba: Professional Writing Services



Pursuant to Title 17 U.S.C. 107, other copyrighted work is provided for educational purposes, research, critical comment, or debate without profit or payment. If you wish to use copyrighted material from this site for your own purposes beyond the 'fair use' exception, you must obtain permission from the copyright owner.

Views are those of authors and not necessarily those of Canada Free Press. Content is Copyright 1997-2014 the individual authors.

Site Copyright 1997-2014 Canada Free Press.Com Privacy Statement


Powered by ExpressionEngine