Subtherapeutic doses

Microdosing: Updating its role in developing new medicines

Author
- American Chemical Society  Wednesday, January 23, 2013
| Print friendly | Email Us

One of yesterday’s most promising new tools for speeding the development of new medicines — “microdosing” — has found niches in that process today, and they include uses unanticipated a decade ago. That topic, an update on microdosing, is the cover story in the current edition of Chemical & Engineering News. C&EN is the weekly newsmagazine of the American Chemical Society, the world’s largest scientific society.

C&EN Senior Editor Celia Henry Arnaud explains that microdosing offered promise for helping pharmaceutical companies identify potential failures earlier, before starting full-fledged clinical trials of a potential new drug. It involves giving subtherapeutic doses — 1 percent of the full dose — to human volunteers after minimal animal testing. Scientists then would use the results to determine whether to move ahead with expensive safety testing in traditional Phase 1 clinical trials. Microdosing promised to become a standard part of drug development, adding a new so-called Phase 0 to that process.

The article points out that occasional Phase 0 clinical trials do, indeed, take place. But microdosing most often is used in “absolute bioavailability studies,” done in parallel with standard clinical trials to determine how much of the drug actually reaches its target tissue to treat the disease. Other uses of microdosing may emerge in the years ahead, the article notes.

More…

Disqus Comments

American Chemical Society, ACS is a congressionally chartered independent membership organization which represents professionals at all degree levels and in all fields of chemistry and sciences that involve chemistry.

Learn more about ACS.






Most Shared CFP stories



What's New On CFP:

  1. Latest American News
    By News on the Net -- --News Headlines
  2. Even Howard Dean says it’s time to walk away from the Iran ‘deal’
    By Robert Laurie -- --American Politics
  3. The RFS Fallacy
    By Institute for Energy Research -- --Global Warming-Energy-Environment
  4. Rights for all…All except Christians
    By Dr. Laurie Roth -- --American Politics
  5. How we ended up with Obama
    By News on the Net -- --Video
  6. Obama Administration Wants to Regulate the Advice We Get From Retirement Planners
    By Heritage Foundation -- --Financial, Business, Economy
  7. Motoring: Honda Civic
    By Tim Saunders -- --Automotive News and Reviews
  8. Latest World News
    By News on the Net -- --News Headlines
  9. British gallery to show work by British artist
    By Tim Saunders -- --Life-Pets-Gardens-Food
  10. Latest Media News
    By News on the Net -- --News Headlines
  11. Drop him like a hot rock
    By Sarge -- --Media - Media Bias
  12. Deadline passes in Iran talks; Kerry refuses to give up on crap deal
    By Dan Calabrese -- --American Politics
  13. The best kept secret behind Israel’s top medical devices
    By Guest Column -- --Medical News
  14. US Republicans Warn World That Obama’s UN Climate Pledge Could Be Undone
    By Guest Column -- --Global Warming-Energy-Environment
  15. Lutheran Pastor Calls for Christian Unity with Bakers, Florists, Caterers, Wedding Boutiques
    By Christian Newswire -- --American Freedom
  16. Ontario’s Tax on Flights Rises on April Fools’ Day
    By Canadian Taxpayers Federation -- --Canada
  17. Latest News on Ebola and Infectious Diseases
    By News on the Net -- --News Headlines
  18. UN Watch statement on today’s urgent session on Boko Haram
    By UN Watch -- --World News
  19. Obama’s Surrender to Iran Postponed
    By Arnold Ahlert -- --Cover Story
  20. Obama’s Virtual War on Israel
    By Alan Caruba -- --Cover Story
  21. Nat Geo’s “Killing Jesus” a Flawed Excursion into Serious Error
    By Rev. Michael Bresciani -- --Christianity - Religion
  22. How Private Exchanges Are Faring in Their Competition With HealthCare.gov
    By Heritage Foundation -- --American Healthcare
  23. Can Argentina Capitalize On Its Vast Shale Reserves?
    By Oilprice.com -- --Global Warming-Energy-Environment
  24. The Struggle in Yemen: A Test for the Arab Collective
    By INSS -- --World News
  25. Palestinian terrorism and justice
    By Barry Shaw -- --World News
  26. The Real Power of the One Percent
    By Cliff Kincaid -- --Cover Story
  27. Notre Dame: Most Catholic University in America-
    By Church Militant -- --Cover Story
  28. Camp Lone Star - Act One: The Government Charade
    By Gary Hunt -- --Cover Story
  29. Old Times are not forgotten in the South
    By Calvin E. Johnson Jr. -- --Cover Story
  30. Apple CEO: Hates Indiana Christians but does business with countries that execute gays, stone women
    By Warner Todd Huston -- --Cover Story


Ford Nation

Why hundreds of thousands of Torontonians supported their conservative crack-smoking mayor











Caruba: Professional Writing Services



Pursuant to Title 17 U.S.C. 107, other copyrighted work is provided for educational purposes, research, critical comment, or debate without profit or payment. If you wish to use copyrighted material from this site for your own purposes beyond the 'fair use' exception, you must obtain permission from the copyright owner.

Views are those of authors and not necessarily those of Canada Free Press. Content is Copyright 1997-2014 the individual authors.

Site Copyright 1997-2014 Canada Free Press.Com Privacy Statement


Powered by ExpressionEngine