Toward a pill to enable celiac patients to eat foods containing gluten


Toward a pill to enable celiac patients to eat foods containing gluten

- American Chemical Society By Justin B. Siegel, Ph.D.  Wednesday, January 30, 2013
| Print friendly | Email Us

Scientists are reporting an advance toward development of a pill that could become celiac disease’s counterpart to the lactase pills that people with lactose intolerance can take to eat dairy products without risking digestive upsets. They describe the approach, which involves an enzyme that breaks down the gluten that causes celiac symptoms, in the Journal of the American Chemical Society.

Justin Siegel, Ingrid Swanson Pultz and colleagues explain that celiac disease is an autoimmune disorder in which the gluten in wheat, rye or barley products causes inflammation in the digestive tract. Enzymes in the stomach break down gluten into smaller pieces, called peptides. For most people, these peptides are harmless. But for the 2 million-3 million Americans with celiac disease, the peptides trigger an autoimmune response and painful symptoms. Currently, the only treatment is a gluten-free diet. However, the scientists reasoned that if an enzyme could further break down the offending peptides in the stomach, celiac patients might be able to eat gluten-containing foods.

They describe discovery of a naturally occurring enzyme that has some of the ideal properties for doing so. The scientists modified the enzyme in the laboratory so that it would meet all the necessary criteria. The new enzyme (called KumaMax) broke down more than 95 percent of a gluten peptide implicated in celiac disease in acidic conditions like those in the stomach. “These combined properties make the engineered [enzyme] a promising candidate as an oral therapeutic for celiac disease,” say the researchers.

Full article

Disqus Comments

American Chemical Society, ACS is a congressionally chartered independent membership organization which represents professionals at all degree levels and in all fields of chemistry and sciences that involve chemistry.

Learn more about ACS.

Most Shared CFP stories

What's New On CFP:

  1. Vox Features Yet Another Climate Science “Denier”
    By Institute for Energy Research -- --Global Warming-Energy-Environment
  2. People aren’t born stupid
    By George Giftos -- --Letter
  3. Pro-Life Senator Rick Santorum Launches Republican Campaign for President
    By News on the Net -- --News Headlines
  4. ISIS Burns 80-Year-Old Christian Woman to Death for Alleged Sharia Violation
    By News on the Net -- --News Headlines
  5. Parents walk out of grad speech when principal attacks cops for “killing young black men”(video)
    By News on the Net -- --News Headlines
  6. Full Disclosure For All!
    By Leigh Bravo -- --Cover Story
  7. SAF Seeks Contempt Against DC For Stall In Wrenn CCW Case
    By Second Amendment Foundation -- --Gun Control - Second Amendment
  8. Senate Passes Anti-Sharia Law Bill
    By News on the Net -- --News Headlines
  9. Rubio warns Christianity faces “real and present danger” of becoming hate speech(video)
    By News on the Net -- --News Headlines
  10. Abortion Activist is Upset That Premature Babies Like This One Survive More Often
    By News on the Net --
  11. Occupy Wall Street organizers out to “swing” Canadian election
    By Judi McLeod -- --Cover Story
  12. So the GOP Must Embrace Evil to Survive. Really?
    By Lloyd Marcus -- --American Politics
  13. Hillary Clinton lied when she swore she would faithfully discharge the duties of Secretary of State
    By Al Kaltman -- --Cover Story
  14. New York Times Still Deceiving About Obamacare
    By Roger Aronoff -- --American Healthcare
  15. Bernie Sanders: We don’t need 23 deodorant choices when children are hungry
    By Dan Calabrese -- --American Politics
  16. Obama’s Floundering Executive Amnesty: Voter Fraud Based on Racial Profiling!
    By John Lillpop -- --American Politics
  17. Looks like your Amnesty order has been judged to be unconstitutional!
    By Dag Barkley -- --Cartoons
  18. Five Reasons Government Debts Aren’t Like Mortgages
    By Canadian Taxpayers Federation -- --Financial, Business, Economy
  19. Pentagon says ‘live anthrax’ inadvertently shipped across US
    By News on the Net -- --News Headlines
  20. Police dog saves partner’s life after ambush attack in Mississippi woods
    By News on the Net -- --News Headlines
  21. Elizabeth Warren Bought Foreclosed Homes to Make a Quick Profit
    By News on the Net --
  22. Thieves Cause Chaos on A and C Trains by Stealing Copper Cable, MTA Says
    By News on the Net -- --News Headlines
  23. Don’t Believe Voter Fraud Happens? Here are Some Examples
    By Heritage Foundation -- --News Headlines
  24. Time to duck-and-cover. Marie Harf promoted - will join Kerry’s ‘Iran nuclear deal’ team
    By Robert Laurie -- --American Politics
  25. Why Americans can’t buy some of the best sunscreens
    By American Chemical Society -- --Medical News
  26. Mud and straw homes could be answer for earthquake regions
    By Guest Column -- --Science-Technology
  27. Veterans plan own film to challenge Hollywood depictions of them
    By News on the Net -- --News Headlines
  28. Planned Parenthood Celebrates Defeat of Bill to Ban Killing Girls in Sex-Selection Abortions
    By News on the Net -- --News Headlines
  29. German Government In Crisis Over Escalating Cost Of Climate Policy
    By Guest Column -- --Global Warming-Energy-Environment
  30. New electronic stent could provide feedback and therapy — then dissolve
    By American Chemical Society -- --Medical News

Caruba: Professional Writing Services