Toward unraveling the Alzheimer’s mystery


Prion-protein-based compounds

Toward unraveling the Alzheimer’s mystery

Author
- American Chemical Society By Witold K. Surewicz, Ph.D.  Wednesday, May 14, 2014
| Print friendly | Email Us

Getting to the bottom of Alzheimer’s disease has been a rapidly evolving pursuit with many twists, turns and controversies. In the latest crook in the research road, scientists have found a new insight into the interaction between proteins associated with the disease. The report, which appears in the journal ACS Chemical Neuroscience,  could have important implications for developing novel treatments.

Witold K. Surewicz, Krzysztof Nieznanski and colleagues explain that for years, research has suggested a link between protein clumps, known as amyloid-beta plaques, in the brain and the development of Alzheimer’s, a devastating condition expected to affect more than 10 million Americans by 2050. But how they inflict their characteristic damage to nerve cells and memory is not fully understood. Recent studies have found that a so-called prion protein binds strongly to small aggregates of amyloid-beta peptides. But the details of how this attachment might contribute to disease — and approaches to treat it — are still up for debate. To resolve at least part of this controversy, Surewicz’s team decided to take a closer look.

Contrary to previous studies, they found that the prion protein also attaches to large fibrillar clumps of amyloid-beta and do not break them down into smaller, more harmful pieces, as once thought. This finding bodes well for researchers investigating a novel approach to treating Alzheimer’s — using prion-protein-based compounds to stop these smaller, toxic amyloid-beta pieces from forming, the authors conclude.

The authors acknowledge funding from the Spitz Brain Health Innovation Fund and National Institutes of Health.

More…

 

Disqus Comments

American Chemical Society, ACS is a congressionally chartered independent membership organization which represents professionals at all degree levels and in all fields of chemistry and sciences that involve chemistry.

Learn more about ACS.






Most Shared CFP stories



What's New On CFP:

  1. New Orleans Cop Shot Dead in Cruiser
    By News on the Net -- --News Headlines
  2. Senate Dems call on Obama to resettle 65,000 Syrian refugees
    By News on the Net -- --News Headlines
  3. Over 100 newspapers dumped in year, ads down 50%, circulation hits bottom
    By News on the Net -- --News Headlines
  4. The Investigators: ALEC - The Backroom Where (Georgia) Laws Are Born(video)
    By News on the Net -- --News Headlines
  5. Three nations altered temperature data, and you can probably guess why
    By Herman Cain -- --Global Warming-Energy-Environment
  6. Wilt Thou Destroy The Righteous With The Wicked?
    By Jimmy Reed -- --American Politics
  7. American dollars bequeathed us Ireland’s successful referendum
    By Judi McLeod -- --Cover Story
  8. Memorial Day 2015
    By Alan Caruba -- --Cover Story
  9. The Congressional Board of Exchange
    By Sandy Stringfellow -- --Cover Story
  10. I’m Standing With Pat
    By Dr. Robert R. Owens -- --Cover Story
  11. Stop Slave Museum Ship Sellout!
    By Nadra Enzi -- --American Politics
  12. Wolf Trap - Act I - Habeas Corpus
    By Gary Hunt -- --American Freedom
  13. Giant sinkhole opens up at Missouri course
    By News on the Net -- --News Headlines
  14. School apologizes for banning Jesus
    By News on the Net -- --News Headlines
  15. Absolutely not the time to be silent
    By Guest Column -- --Letter
  16. Irish voters back gay marriage in ‘social revolution’
    By News on the Net -- --News Headlines
  17. Obama’s Policies to Empower ISIS Exposed
    By Raymond Ibrahim -- --Cover Story
  18. Wolf Trap - Act I - Habeas Corpus
    By Gary Hunt -- --American Freedom
  19. Republicans lose faith in Party Leadership
    By Jeff Crouere -- --Cover Story
  20. The Jefferson Davis ‘Memorial Day’ Funeral Train
    By Calvin E. Johnson Jr. -- --Cover Story
  21. De-Islamization is the Only Way to Fight ISIS
    By Daniel Greenfield -- --Crime-Terror-Security
  22. End this Tyranny
    By Guest Column -- --American Freedom
  23. Shavou’ot (Pentecost) highlights US-Israel relations
    By Yoram Ettinger -- --Christianity - Religion
  24. Camp Lone Star - Nor Shall Private Property be Taken…
    By Gary Hunt -- --American Freedom
  25. Obama Establishes New Cabinet-Level Position: Appoints Mitch McConnell
    By John Lillpop -- --American Politics
  26. Facebook to conservative user: Picture of lilac tree considered ‘pornographic’
    By News on the Net -- --News Headlines
  27. IMF’s Disingenuous Attempt to Tax Energy Use
    By Institute for Energy Research -- --Global Warming-Energy-Environment
  28. Las Vegas feels magnitude-4.8 earthquake 100 miles away
    By News on the Net -- --News Headlines
  29. Oh joy: Hillary offers her thoughts on how to ‘jump start small business’
    By Dan Calabrese -- --American Politics
  30. Kirsten Powers on the War Against Free Speech and Why Most on the Left Don’t Get It
    By Heritage Foundation -- --News Headlines










Caruba: Professional Writing Services