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Study: A protein called Erbin plays a role in abnormal heart enlargement, which is one side effect of a common drug to treat breast cancer.

Heart research sheds light on breast cancer



‘I want to study women [with breast cancer] who have developed cardiotoxicity to measure the Erbin in their hearts and find any correlations, says researcher Inbal Rachmin.

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The actress Angelina Jolie shocked the world when she announced she was having a double mastectomy. As a carrier of the BRCA1 gene, she had an 87 percent risk of developing breast cancer and chose the surgery to reduce her risk. Now, new research from Israel points to better outcomes for those being treated or who are at risk. They focused on a protein called Erbin that seems to be linked to heart disease – specifically an abnormally enlarged heart, as Rachmin and her team reported in the Proceedings of the National Academy of Sciences (PNAS). “We were the first one to publish about Erbin’s role in the heart, not only in mice models but in humans,” Rachmin tells ISRAEL21c. “There was only one article that showed expression in cell lines but didn’t show any physiological function like we did.” More...


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