John Ioannidis first burst onto the national scene in 2005 with a groundbreaking paper titled “Why Most Published Research Findings Are False.” 1 His statistical analysis and logic are impeccable, and his paper has never been seriously refuted. Furthermore, he has had a tremendous impact: the paper has been viewed more than 2.5 million times.2
Since then, Ioannidis has gone on to show that the best scientists don’t always get funded, why neuroscience is unreliable, why most clinical research is useless, and that most economic studies are exaggerated. In other words, the process by which we acquire new knowledge is fundamentally flawed and much of what we think we know is wrong2
These days he’s aimed his attacks at nutrition research and guidelines on disease definition statements.