American Chemical Society, One drug, many diseases
It seems too good to be true: a single drug that could treat humanity’s worst afflictions, including atherosclerosis, cancer, Alzheimer’s, Parkinson’s and arthritis. All of these diseases have one thing in common –– they involve an inflammatory protein called NLRP3. Now, biotech start-ups and pharmaceutical companies are racing to develop drugs that inhibit the function of this protein, according to an article in Chemical & Engineering News (C&EN), the weekly newsmagazine of the American Chemical Society.
- Sunday, February 23, 2020
In ancient Greek mythology, Icarus’ wax wings melted when he dared to fly too close to the sun. Now, researchers reporting in ACS Applied Materials & Interfaces have made artificial wings that are actually powered by the sun. The tiny wings, which can flap even faster than those of butterflies, could someday be used in robots or devices for solar energy harvesting, the researchers say.
Despite its newfound notoriety, coronaviruses actually represent a large family of human respiratory viruses, including the common cold and more serious diseases, such as severe acute respiratory syndrome (known as SARS). This group of viruses can also be transmitted between humans and animals, leading to further complications in disease containment and treatment.
Lithium-ion batteries are in everything from cell phones to cars. However, recent incidents involving fires or explosions of these devices show there’s a need for safer batteries. One option is to replace the flammable liquid electrolyte with a solid-state electrolyte (SSE). But some of the most-studied SSEs are themselves flammable, leaving the original safety concern unaddressed. Researchers now report in ACS’ Nano Letters that they have developed an SSE that won’t burn up.
Traditional lithium-ion batteries consist of a cathode and anode, separated by a liquid electrolyte and a thin piece of porous plastic. If the battery is damaged — for example, if it is overcharged or if needlelike lithium projections grow and pierce the plastic separator — the electrolyte can catch fire. Scientists have experimented with a variety of solutions, such as adding fire retardants to the electrolyte, or replacing the soft and flammable separator and electrolyte with an SSE.
Brain-eating amoebae can cause particularly harmful forms of encephalitis, and more than 95% of people who develop these rare but devastating infections die. Despite the high mortality rate, there is currently no single effective drug available to fight these microbes. Now, however, researchers have designed some new compounds that show promise in the laboratory as treatments, according to a report in ACS Chemical Neuroscience.
The abuse of prescription and illegal opioids, such as morphine and heroin, is a major problem in the U.S., with devastating public health, economic and social consequences. That’s why scientists are searching for new medicines to help break the cycle of addiction. Now, researchers reporting in ACS’ Journal of Medicinal Chemistry have re-engineered the structure of vincamine, a plant-derived compound, so that it reduces morphine-seeking behaviors in mice.
These days, many people are concerned about plastic waste; however, the convenience, mechanical properties and cost of plastic food packaging are hard to beat. But now, a growing number of innovators and entrepreneurs are trying to make edible packaging and tableware from foods like seaweed, milk proteins and potato starch.
In addition to harmful gases such as carbon monoxide, air pollution contains tiny particles that have been linked to health problems, including cardiovascular disease and asthma. Most studies have analyzed the potential health effects of larger-sized particulate matter (PM), such as particles less than 2.5 μm in diameter (PM2.5). Now, researchers report in Environmental Science & Technology Letters that particles with diameters less than 1 μm (PM1) are even more strongly correlated with cardiovascular disease.
According to the World Health Organization, antibiotic resistance is one of the biggest threats to global health. Sensing and treating bacterial infections earlier could help improve patients’ recovery, as well curb the spread of antibiotic-resistant microbes. Now, researchers reporting in ACS Central Science have developed color-changing bandages that can sense drug-resistant and drug-sensitive bacteria in wounds and treat them accordingly.
Foxtail millet is an annual grass grown widely as a cereal crop in parts of India, China and Southeast Asia. Milling the grain removes the hard outer layer, or bran, from the rest of the seed. Now, researchers have identified a protein in this bran that can help stave off atherosclerosis in mice genetically prone to the disease. They report their results in ACS’ Journal of Agricultural and Food Chemistry.
Cavities, or dental caries, are the most widespread non-communicable disease globally, according to the World Health Organization. Having a cavity drilled and filled at the dentist’s office can be painful, but untreated caries could lead to worse pain, tooth loss, infection, and even illness or death. Now, researchers in ACS Applied Materials & Interfaces report a bioactive peptide that coats tooth surfaces, helping prevent new cavities and heal existing ones in lab experiments.
Police have long relied on the unique whorls, loops or arches encoded in fingerprints to identify suspects. However, they have no way to tell how long ago those prints were left behind — information that could be crucial to a case. A preliminary new study in ACS’ Analytical Chemistry suggests that could change. Researchers report that they could link compounds contained in fingerprints with their age.
Printed circuit boards are vital components of modern electronics. However, once they have served their purpose, they are often burned or buried in landfills, polluting the air, soil and water. Most concerning are the brominated flame retardants added to printed circuit boards to keep them from catching fire. Now, researchers reporting in ACS Sustainable Chemistry & Engineering have developed a ball-milling method to break down these potentially harmful compounds, enabling safer disposal.
Throughout history, people have sought vibrant blue pigments. The Egyptians and Babylonians used lapis lazuli 6,000 years ago. In 1802, a French chemist synthesized cobalt blue. More recently, in 2009 scientists discovered YInMn Blue, otherwise known as “Oregon Blue.” But most of these pigments have limitations in terms of cost, stability, color or toxicity. Now, researchers in ACS Omega report a new class of ‘cool’ blue colorants that are inexpensive, durable and more environmentally friendly.
WASHINGTON--People have been developing different forms of shark repellent for decades — the military even issued a chemical shark repellent called “Shark Chaser” to pilots, sailors and astronauts(!) from the end of World War II through the start of the Vietnam War. Thing is … it didn’t really work. Learn why they bothered passing it out or even created it in the first place:
E-cigarette use is rising, particularly among young adults and teens. Recent illnesses and deaths attributed to vaping have caused intense scrutiny of the chemicals in e-liquids and vapor, but little is known about the size of vaping particles and their deposition patterns in human airways.
After a day hiking in the forest, the last thing a person wants to discover is a tick burrowing into their skin. Days after plucking off the bloodsucking insect, the hiker might develop a rash resembling a bull’s-eye, a tell-tale sign of Lyme disease. Yet not everybody who contracts Lyme disease gets the rash. Now, researchers reporting in ACS Nano have devised a blood test that quickly and sensitively diagnoses the disease at early stages.
During storms in the southwestern U.S., some rattlesnakes drink rain droplets from scales on their backs. This unusual behavior could help them survive in a desert environment with infrequent rain. Now, researchers have figured out how the nanotexture of scales from these snakes helps them use their bodies to harvest rain. They report their results in in ACS Omega. Watch a video about the snake scales here.
WASHINGTON--There are tens of thousands of mushroom species out there, and some of them could kill you. Today we’re going to test how well you can distinguish between perfectly safe and perilously poisonous, and we’ll dive into the chemistry behind what makes seemingly identical species so different:
Amid concerns about gluten sensitivity, increasing numbers of people are avoiding wheat. Most have not been diagnosed with a wheat-related medical condition, yet they seem to feel better when they don’t eat gluten-containing foods. A possible explanation is that modern varieties of wheat are responsible. But now, researchers reporting in ACS’ Journal of Agricultural and Food Chemistry have shown that a popular modern variety does not impair gastrointestinal health in mice compared with heirloom wheat.