Procedure was part of a clinical trial of human bone tissue grown in a bioreactor from fat cells of the same patient, eliminating risk of rejection

In world first, Israeli man gets injected shinbone graft

By —— Bio and Archives--December 27, 2017

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In world first, Israeli man gets injected shinbone graft
A rare bone implant was performed on an Israeli man at Emek Medical Center in Afula. The patient has been missing 5 centimeters (about 2 inches) of his tibia (shinbone) as the result of injuries sustained in a car accident eight months ago.

Normally, the human body is not capable of naturally restoring bone segments. The experimental procedure led by Dr. Nimrod Rozen, head of orthopedics at Emek, was part of an ongoing clinical trial of a revolutionary tissue-engineering technology developed by Bonus BioGroup of Haifa.

Fat cells previously extracted from the patient were grown on a biological scaffold in Bonus BioGroup’s lab for two weeks. Semi-solid live bone tissue grown from these fat cells was then injected back into the patient’s body in the expectation that the missing bone fragment will be regenerated in about six weeks.

“This surgery is truly science fiction; it changes the entire game in orthopedics,” Rozen told Yedioth Ahronoth.

Last August, as part of the same clinical trial expected to include up to 40 men and women, a similar procedure was performed on a 40-year-old patient suffering significant bone loss in his arm as the result of a car accident. This surgery also was led by Rozen, one of three doctors on Bonus BioGroup’s scientific advisory board.—More…


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