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Breakthrough development uses a patient's own stomach cells, cutting the risk of an immune response to implanted organs

Israeli scientists develop implanted organs that won’t be rejected


By —— Bio and Archives--November 14, 2018

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Israeli scientists develop implanted organs that won’t be rejected
Israeli researchers report that they have invented the first fully personalized tissue implant, engineered from a patient’s own materials and cells. The new technology makes it possible to engineer any kind of tissue implant, for the spinal cord, to the heart, or brain, from one small fatty tissue biopsy.

“We were able to create a personalized hydrogel from the materials of the biopsy, to differentiate fatty tissue cells into different cell types and to engineer cardiac, spinal cord, cortical and other tissue implants to treat different diseases,” said lead researcher Prof. Tal Dvir of Tel Aviv University’s Center for Nanoscience and Nanotechnology and Sagol Center for Regenerative Biotechnology.

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Avoiding anti-rejection drugs

“Since both the cells and the material used derive from the patient, the implant does not provoke an immune response, ensuring proper regeneration of the defected organ,” Dvir explained.

The research was conducted by Dvir’s postdoctoral researcher, Reuven Edri, and doctoral students Nadav Noor and Idan Gal, in collaboration with Prof. Dan Peer and Prof. Irit Gat Viks of TAU’s Department of Cell Research and Immunology and Prof. Lior Heller of Assaf HaRofeh Medical Center in Israel. It was recently published in the journal Advanced Materials.

Currently, in tissue engineering for regenerative medicine, cells are isolated from the patient and cultured in biomaterials to assemble into a functional tissue. These biomaterials can be synthetic or natural, derived from plants or animals.

After transplantation, they may induce an immune response that leads to rejection of the implanted tissue. Patients receiving engineered tissues or any other implants are treated with immuno-suppressors, which unfortunately can endanger the health of the patient. —More…


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