Israeli researchers discover survival rates in pancreatic cancer linked to inverse correlation between specific oncogene and tumor suppressant

New nanomedicine could prevent progression of pancreatic cancer

By —— Bio and Archives--January 24, 2018

Health and Medicine | Comments | Print Friendly | Subscribe | Email Us

New nanomedicine could prevent progression of pancreatic cancer
A new study published in scientific journal Nature Communications distinguishes the reason for extended pancreatic cancer survival: an inverse correlation between a known oncogene, a gene that promotes the development of cancer, and the expression of an oncosuppressor microRNA.

Though 75 percent of pancreatic cancer patients die within 12 months of diagnosis, about 7% survive more than five years. “We thought that if we could understand how some people live several years with this most aggressive disease, we might be able to develop a new therapeutic strategy,” said lead researcher Prof. Ronit Satchi-Fainaro, chair of physiology and pharmacology at Tel Aviv University’s Sackler Faculty of Medicine.

She worked with Hadas Gibori and Shay Eliyahu, both members of her laboratory, in collaboration with Prof. Eytan Ruppin of TAU’s computer science department and the University of Maryland and Prof. Iris Barshack and Dr. Talia Golan of Chaim Sheba Medical Center at Tel Hashomer, Ramat Gan. Other authors of the paper include two researchers from The Institute for Drug Research in the Hebrew University of Jerusalem’s School of Pharmacy.

The research team examined pancreatic cancer cells in mouse models and discovered an inverse correlation between the signatures of miR-34a, a tumor suppressant, and PLK1, a known oncogene. The levels of miR-34a were low in pancreatic cancer mouse models, while the levels of the oncogene were high. This correlation made sense for such an aggressive cancer.

RNA profiling and analysis of samples taken by the researchers from pancreatic cancer patients revealed the same genomic pattern in humans as was seen in the mouse models.

Calling a nano-taxi

The scientists then devised a novel nanoparticle that selectively delivers genetic material to a tumor and prevents side effects in surrounding healthy tissues.—More…


Please SHARE this story as the only way for CFP to beat Facebook anti-Conservative Suppression.

Only YOU can save CFP from Social Media Suppression. Tweet, Post, Forward, Subscribe or Bookmark us

ISRAEL21c -- Bio and Archives | Comments

ISRAEL21c was founded in 2001, in the wake of the Second Intifada, to broaden public understanding of Israel beyond typical portrayals in the mainstream media.

The organization’s founders – Israeli-American technology executives – understood the great power of the Internet and developed a first-of-its kind online product with global appeal and reach.

Commenting Policy

Please adhere to our commenting policy to avoid being banned. As a privately owned website, we reserve the right to remove any comment and ban any user at any time.

Comments that contain spam, advertising, vulgarity, threats of violence, racism, anti-Semitism, or personal or abusive attacks on other users may be removed and result in a ban.
-- Follow these instructions on registering: