"This is completely out of character for Denise," the woman's brother, Cedric Thiem, told FoxNews.com Thursday, saying he communicated "every other day" with his sister through Skype or e-mail.
Mystery surrounds disappearance of American woman on ancient Catholic pilgrimage in Spain
Denise Thiem's trek in April across the ancient Catholic pilgrimage known as the Camino de Santiago was meant to be a soul-searching expedition for the American tourist, who quit her job in Arizona last year to travel the world.