One drug could treat Alzheimer’s, MS, Crohn’s and more

Could one drug effectively treat incurable inflammatory diseases such as Crohn’s disease, ulcerative colitis, rheumatoid arthritis and multiple sclerosis as well as neurodegenerative maladies such as Alzheimer’s disease? Yes, says Prof. David Naor, speaking with ISRAEL21c at the Lautenberg Center for General and Tumor Immunology in Hebrew University-Hadassah Medical School, Jerusalem.

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All these diseases are associated with pathological amyloid proteins

All these diseases, he explains, are associated with pathological amyloid proteins that could be neutralized by the 5-mer peptide Naor has spent the last 10 years researching and developing with the support of the university’s Yissum technology-transfer company, the Israeli government and Spherium Biomed of Spain. It will take several million dollars to start clinical trials of Naor’s novel, IP-protected peptide — a synthetic protein snippet that significantly reverses the damaging effects of inflammatory diseases and Alzheimer’s disease in mouse models, and restores the learning capacity of Alzheimer’s mice. “I believe that within two years we would know for certain if our academic product can translate into a therapeutic drug to combat inflammatory and neurodegenerative diseases,” Naor says. “Once you control the inflammation, you can control the disease, so our target is to reduce as much as possible the inflammatory activity.”-- More...

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