Promise of psoriasis cure on the horizon

About four million Americans suffer from psoriasis, a chronic autoimmune skin disease that causes patches of inflamed, silvery-white scabs. There is no cure for the condition, but Israeli researchers believe they may be on the road to formulating a groundbreaking drug candidate that could finally do the job.

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As described in the journal Chemistry and Biology by the team from Ben-Gurion University of the Negev (BGU), their study in collaboration with Israel’s Teva Pharmaceutical Industries showed that inhibiting the immune system protein Interleukin 17 (IL-17) could be the key to controlling the skin disease. “Psoriasis is mediated by pro-inflammatory cytokines,” explains lead researcher Prof. Amir Aharoni. “One of the main cytokines that plays a role in this and other autoimmune diseases is IL-17. Our goal was to inhibit IL-17’s action and slow the progression of several of these diseases.” Once they mastered the methodology using animal models, they looked for the best indication on which to test it. They zeroed in on psoriasis because previous studies showed IL-17 to be particularly important in its progression. More...

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