WhatFinger
CFPSubcribe

Israeli human-on-a-chip platform has the unique ability to predict risk of toxicity in pharma and cosmetic product candidates without animal testing

Radical new drug-testing tech could dramatically cut animal testing


By —— Bio and Archives--August 2, 2017

Health and Medicine | Comments | Print Friendly | Subscribe | Email Us

After spending an average of $2.5 billion to develop a single new drug, sometimes pharma companies have to pull it from the market due to a bad outcome that was not detected in clinical studies.

That’s what happened in 2000, when a promising Type 2 diabetes drug called troglitazone led to idiosyncratic (unexplained) liver damage in one of every 60,000 users.

The troglitazone mystery wasn’t solved until March 2016, when a novel “liver-on-a-chip” platform developed by Hebrew University of Jerusalem Prof. Yaakov Nahmias revealed what no animal or human tests could: even low concentrations of this drug caused liver stress before any damage could be seen.

“It was the first time an organ-on-chip device could predict information to help pharmaceutical companies define risk for idiosyncratic toxicity,” Nahmias tells ISRAEL21c.—More…


Please SHARE this story as the only way for CFP to beat Facebook anti-Conservative Suppression.

Only YOU can save CFP from Social Media Suppression. Tweet, Post, Forward, Subscribe or Bookmark us

ISRAEL21c -- Bio and Archives | Comments

ISRAEL21c was founded in 2001, in the wake of the Second Intifada, to broaden public understanding of Israel beyond typical portrayals in the mainstream media.

The organization’s founders – Israeli-American technology executives – understood the great power of the Internet and developed a first-of-its kind online product with global appeal and reach.


Commenting Policy

Please adhere to our commenting policy to avoid being banned. As a privately owned website, we reserve the right to remove any comment and ban any user at any time.

Comments that contain spam, advertising, vulgarity, threats of violence and death, racism, anti-Semitism, or personal or abusive attacks on other users may be removed and result in a ban.
-- Follow these instructions on registering: