Lava lamps, tambourines and, of course, psychedelic drugs were hallmarks of the 1960s. Psychedelic drugs can make people euphoric, though users can also become extremely anxious and agitated. But that’s at a high dose. Now, in ACS Chemical Neuroscience, researchers report one of the first peer-reviewed studies on a new “microdose” psychedelic treatment regimen. In rats, the treatment appears to relieve anxiety and depression without the typical negative effects of the drugs.