We see these startling headlines every day: Limonene in oranges causes kidney cancer in rats! Alar in apples causes cancer in mice! The sweetener saccharin causes bladder cancer in rats! These reports usually focus on a chemical present in the environment that produces cancer in a laboratory animal test with the implication that it will also cause cancer in humans. The question is—what are we to believe about the headlines making a connection between animal studies and potential effects on humans? (1)