A U.S. Department of Justice report by the National Drug Intelligence Center (NDIC) says that Mexican drug gangs pose the biggest organized crime threat to the United States. The report, the annual National Drug Threat Assessment 2009, evaluates the threat posed by illegal drugs by examining availability, production and cultivation, transportation, distribution, and demand. The study estimates that Mexican and Colombian drug trafficking organizations make and launder between $18 billion and $39 billion in wholesale drug profits annually. Mexican drug smugglers control most of the U.S. drug markets, smuggling most of the cocaine available in the U.S. across the U.S./Mexico border.