“This overall strategy represents a platform technology that may be readily applied to other therapies with limited brain penetration,” such as anticancer and anti-schizophrenia drugs, say the researchers.
Potential new drugs plug brain’s biological “vacuum cleaner” and target HIV
Journal of the American Chemical Society
In an advance toward eliminating pockets of infection in the brain that help make HIV disease incurable, scientists report the development of new substances that first plug the biological vacuum cleaner that prevents anti-HIV drugs from reaching the brain and then revert to an active drug to treat HIV. They describe the advance, which allows medications to cross the so-called “blood-brain barrier” (BBB) and treat brain diseases, in the Journal of the American Chemical Society.
