You might recall that one of the tactics tried by the Remain crowd prior to last week's Brexit vote was have Barack Obama - standing in the presence of British Prime Minister David Cameron - essentially threaten the UK with being sent to the "back of the queue" for purposes of getting any bilateral trade deal negotiated with the United States. Stay in the EU, Obama basically said, because we work out trade deals with transnational outfits and not with individual allies.
That proposition is absurd on its face, but it's also no way to treat one of your longest standing allies. It was probably a bluff too, since it's certainly not in the interests of the United States to be lacking a coherent trade relationship with Britain. You might never hear Obama say that, because he boxed himself into a corner with his threat, and his presidency will be over before he has to address it anyway.